ARTICLES CIENTÍFICS

2021

• Ávila-Román, J. et al. 2021. Phenolic compounds and biological rhythms: Who takes the lead?, Trends in Food Science & Technology. 113:77-85.
• Ávila-Román, J. et al., 2021 Impact of gut microbiota on plasma oxylipins profile under healthy and obesogenic conditions. Clinical nutrition (Edinburgh, Scotland), 40,4:1475-1486
• Gil-Cardoso, K. et al. 2021. Consumption of Sourdough Breads Improves Postprandial Glucose Response and Produces Sourdough-Specific Effects on Biochemical and Inflammatory Parameters and Mineral Absorption. Journal of agricultural and food chemistry, 69(10), 3044-3059. https://doi.org/10.1021/acs.jafc.0c07200
• Grau-Bové, C. et al. 2020. Modulation of Food Intake by Differential TAS2R Stimulation in Rat. Nutrients 12, no. 12: 3784. https://doi.org/10.3390/nu12123784
• Hernandez-Baixauli, J. et al. 2021. A Pilot Study for Metabolic Profiling of Obesity-Associated Microbial Gut Dysbiosis in Male Wistar Rats . Biomolecules 11, no. 2: 303. https://doi.org/10.3390/biom11020303
• Hernandez-Baixauli, J. et al., 2021 A Pilot Study for Metabolic Profiling of Obesity-Associated Microbial Gut Dysbiosis in Male Wistar Rats. Biomolecules 11,2:303
• López-Fernández-Sobrino R. et al. 2021 Blood Pressure-Lowering Effect of Wine Lees Phenolic Compounds Is Mediated by Endothelial-Derived Factors: Role of Sirtuin 1. Antioxidants. 10(7):1073. https://doi.org/10.3390/antiox10071073
• López-Fernández-Sobrino, R. et al., 2021. ACE Inhibitory and Antihypertensive Activities of Wine Lees and Relationship among Bioactivity and Phenolic Profile. Nutrients. 13:679
• López-Fernández-Sobrino, R. et al., 2021. Blood Pressure-Lowering Effect of Wine Lees: Dose-Response Study, Effect of Dealcoholization and Possible Mechanisms of Action. Nutrients 13(4):1142
• López-Fernández-Sobrino, R. et al., 2021. Enzyme-Assisted Extraction to Obtain Phenolic-Enriched Wine Lees with Enhanced Bioactivity in Hypertensive Rats. Antioxidants (Basel) 10(4):517
• Marinho, S. et al., 2021 Anti-Inflammatory Effects of Rosmarinic Acid-Loaded Nanovesicles in Acute Colitis through Modulation of NLRP3 Inflammasome. Biomolecules  11,2:162
• Martín-González, M.Z. et al., 2021. A multifunctional ingredient for the management of metabolic s-yndrome in cafeteria diet-fed rats. Food Funct. DOI: 10.1039/d0fo02810j.
• Monfoulet, L. E. et al. 2021. Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies. Molecular nutrition & food research, e2100227. Advance online publication. https://doi.org/10.1002/mnfr.202100227
• Monfoulet, L.-E. et al. (2021), Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data From a Systematic Review of Animal Studies. Mol. Nutr. Food Res.. Accepted Author Manuscript 2100227.
• Paton, B. et al. 2021. Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan Analysis Int. J. Mol. Sci. 22, no. 11: 5788.
• Rodríguez-Luna, A. et al. Preparation and In Vivo Evaluation of Rosmarinic Acid-Loaded Transethosomes After Percutaneous Application on a Psoriasis Animal Model. AAPS PharmSciTech 22,3:103
• Sánchez-Velázquez, O. A. et al. (2021). In vitro gastrointestinal digestion impact on stability, bioaccessibility and antioxidant activity of polyphenols from wild and commercial blackberries (Rubus spp.). Food & function, 10.1039/d1fo00986a. Advance online publication. https://doi.org/10.1039/d1fo00986a
• Tomas-Hernandez, S. et al. 2021. Anti-Inflammatory and Immunomodulatory Effects of the Grifola frondosaNatural Compound o-Orsellinaldehyde on LPS-Challenged Murine Primary Glial Cells. Roles of NF-κβ and MAPK Pharmaceutics 13, no. 6: 806.
• Tomas-Hernandez, S. et al. 2021. Anti-Inflammatory and Immunomodulatory Effects of the Grifola frondosa Natural Compound o-Orsellinaldehyde on LPS-Challenged Murine Primary Glial Cells. Roles of NF-κβ and MAPK. Pharmaceutics 13, no. 6: 806. https://doi.org/10.3390/pharmaceutics13060806
• Valls, R. M. et al. 2021. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). European journal of nutrition, 60(3), 1277-1288. https://doi.org/10.1007/s00394-020-02279-0

2020

• Alcaide-Hidalgo, J.M et al., 2020. [Virgin olive oil (unfiltered) extract contains peptides and possesses ACE inhibitory and antihypertensive activity.](https://www.clinicalnutritionjournal.com/article/S0261-5614(19)30227-4/fulltext) Clin. Nutr. 39: 1242e1249.
• Ardid-Ruiz, A. et al., 2020. The effects of *Vitis vinifera L.* phenolic compounds on a blood-brain barrier culture model: Expression of leptin receptors and protection against cytokine-induced damage. J. Ethnopharmacol. 247: 112253.
• Arola-Arnal, A. et al., 2020. Exosomes transport trace amounts of (poly)phenols. Food Funct. 11: 7784.
• Blanco, J. et al., 2020.Obesogenic effects of chlorpyrifos and its metabolites during the differentiation of 3T3-L1 preadipocytes. Food Chem. Toxicol. 137:111171.
• Calderón-Pérez, L. et al., 2020. Acute Effects of turmeric extracts on knee joint pain: A pilot, randomized controlled trial. J. Med. Food. DOI: 10.1089/jmf.2020.0074 .
• Cruz-Carrión, A. et al., 2020. Oxidative stress in rats is modulated by seasonal consumption of sweet cherries from different geographical origins: Local vs. Non-local. Nutrients. 12: 2854.
• Gibert-Ramos, A. et al., 2020. A Mix of natural bioactive compounds reduces fat accumulation and modulates gene expression in the adipose tissue of obese rats fed a cafeteria diet. Nutrients. 12 (11): 3251.
• Gibert-Ramos, A. et al., 2020. Consumption of out-of-season orange modulates fat accumulation, morphology and gene expression in the adipose tissue of Fischer 344 rats. Eur J Nutr. 59:621-631.
• Gimeno, A. et al., 2020. Understanding the variability of the S10 pocket to improve matrix metalloproteinase inhibitor selectivity profiles. Drug Discov. Today. 25(1):38-57.
• Gutiérrez, M. et al., 2020. New eunicellin-type diterpenes from the panamanian octocoral Briareum asbestinum. Mar. Drugs. 18:84.
• Jimenez-Lamana, j. et al., 2020. Nickel nanoparticles induce the synthesis of a tumor-related polypeptide in human epidermal keratinocytes. Nanomaterials. 10: 992.
• Jové, M. et al., 2020. Molecular phenomics of a high-calorie diet-induced porcine model of prepubertal obesity. J. Nutr. Biochem. 83:108393.
• Martín-González, M.Z. et al., 2020. A novel dietary multifunctional ingredient reduces body weight and improves leptin sensitivity in cafeteria diet-fed rats. J. Funct.Foods. 73: 104141.
• Martín-González, M.Z. et al., 2020. Beneficial effects of a low-dose of conjugated linoleic acid on body weight gain and other cardiometabolic risk factors in cafeteria diet-fed rats.Nutrients. 12: 408.
• Mas-Capdevila, A. et al., 2020. Changes in arterial blood pressure caused by long-term administration of grape seed proanthocyanidins in rats with established hypertension. Food Funct. 11:8735.
• Mas-Capdevila, A. et al., 2020. Implication of opioid receptors in the antihypertensive effect of a novel chicken foot-derived peptide. Biomolecules. 10: 992.
• Palacios-Jordán, H. et al., 2020. The disruption of liver metabolic circadian rhythms by a cafeteria diet is sex-dependent in Fischer 344 rats. Nutrients. 12: 1085.
• Pla-Pagà, L. et al., 2020. Proteomic analysis of heart and kidney tissues in healthy and metabolic syndrome rats after hesperidin supplementation. Mol. Nutr. Food Res. 64:1901163.
• Quesada-Vázquez, S et al., 2020. Diet, gut microbiota and non‐alcoholic fatty liver disease: Three parts of the same axis. Cells. 9:176.
• Ruskovska, T. et al., 2020. Systematic bioinformatic analysis of nutrigenomic data of flavanols in cell models of cardiometabolic disease. Food Funct. 11:5040.
• Schellekens, H. et al., 2020. [Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human](https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(20)30552-1/fulltext). eBioMedicine. DOI: 10.1016/j.ebiom.2020.103176 .
• Valls, R. M. et al., 2020. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). Eur. J. Nutr. DOI: 10.1007/s00394-020-02279-0.

2019

• Angelino, D. et al., 2019. 5-(Hydroxyphenyl)-valerolactone-sulfate, a key microbial metabolite of flavan-3-ols, is able to reach the brain: evidence from different in silico, in vitro and in vivo experimental models. Nutrients. 11: 2678.
• Ardid-Ruiz, A. et al., 2019. Resveratrol treatment enhances the cellular response to leptin by increasing obrb content in palmitate-induced steatotic HepG2 cells. Int. J. Mol. Sci.20:6282.
• Arola-Arnal. A. et al., 2019. Chrononutrition and polyphenols: Roles and diseases. Nutrients. 11: 2602.
• Bravo, F.I. et al., 2019. Novel antihypertensive peptides derived from chicken foot proteins. Mol. Nutr. Food. Res. 63:1801176.
• Casanova-Martí, A. et al., 2019. Antihyperglycemic effect of a chicken feet hydrolysate via the incretin system: DPP-IVinhibitory activity and GLP-1 release stimulation. Food Funct. 10:4062.
• Casanova, E. et al., 2019. Epigallocatechin gallate modulates muscle homeostasis in Type 2 Diabetes and obesity by targeting energetic and redox pathways: a narrative review.Int. J. Mol. Sci. 20:532.
• Del Bas, J.M. et al., 2019. Hepatic accumulation of S-Adenosylmethionine in hamsters with non-alcoholic-fatty liver disease associated to metabolic syndrome under selenium and vitamin E deficiency. Clin Sci (Lond). 133 (3):409-423.
• Domenech-Coca, C. et al., 2019. Dual liquid-liquid extraction followed by LC-MS/MS method for the simultaneous quantification of melatonin, cortisol, triiodothyronine, thyroxine and testosterone levels in serum: Applications to a photoperiod study in rats. J. Chromatogr. B. 1108:11-16.
• Gibert-Ramos, A. et al., 2019. Response to the photoperiod in the white and brown adipose tissues of Fischer 344 rats fed a standard or cafeteria diet. *J. Nutr. Biochem. 70:82-90.
• Gimeno, A. et al., 2019. The light and dark sides of virtual screening: what is there to know?. Int. J. Mol. Sci. 20:1375.
• Gual-Grau, A. et al., 2019. Impact of different hypercaloric diets on obesity features in rats: a metagenomics and metabolomics integrative approach. J. Nutr. Biochem. 71:122-131.
• Guirro, M. et al., 2019. Comparison of metaproteomics workflows for deciphering the functions of gut microbiota in an animal model of obesity. J. Proteomics. 209:103489.
• Guirro, M. et al., 2019. Effects from diet-induced gut microbiota dysbiosis and obesity can be ameliorated by fecal microbiota transplantation: A multiomics approach. Plos One. 14 (9):e0218143.
• Iglesias-Carres, L.et al., 2019. A comparative study on the bioavailability of phenolic compounds from organic and nonorganic red grapes. Food Chem. 299:125092.
• Iglesias-Carres, L.et al., 2019. Exposure of Fischer 344 rats to distinct photoperiods influences the bioavailability of red grape polyphenols. J. Photoch. Photobio. B. 199:11162.
• Iglesias-Carres, L.et al., 2019. Optimization and characterization of Royal Dawn cherry (Prunus avium) phenolics extraction. Sci. Reports. 9:17626.
• Iglesias-Carres, L.et al., 2019. Optimization of a polyphenol extraction method for sweet orange pulp (Citrus sinensis L.) to identify phenolic compounds consumed from sweet oranges. Plos One. 14 (1): e0211267.
• Iglesias-Carres, L.et al., 2019. Optimization of extraction methods for characterization of phenolic compounds in apricot fruit (Prunus armeniaca). Food Funct. 10:6492.
• Mandracchia, F. et al., 2019. Potential use of mobile phone applications for self-monitoring and increasing daily fruit and vegetable consumption: a systematized review. Nutrients.11:686.
• Mariné-Casadó, et al. 2019. Cherry consumption out of season alters lipid and glucose homeostasis in normoweight and cafeteria-fed obese Fischer 344 rats. J Nutr Biochem. 63:72-86.
• Mas-Capdevila, A. et al., 2019. Evidence that nitric oxide is involved in the blood pressure lowering effect of the peptide AVFQHNCQE in spontaneously hypertensive rats. Nutrients. 11 (2):225.
• Mas-Capdevila, A. et al., 2019. Long-term administration of protein hydrolysate from chicken feet induces antihypertensive effect and confers vasoprotective pattern in diet-induced hypertensive rats. J. Funct. Foods, 55:28-35.
• Mayneris-Perxachs, J. et al., 2019. Supplementation with biscuits enriched with hesperidin and naringenin is associated with an improvement of the Metabolic Syndrome induced by a cafeteria diet in rats. J. Funct. Foods. 61:103504.
• Miró-Abella, E. et al., 2019. Optimised extraction methods for the determination of trichothecenes in rat faeces followed by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B. 1105:47-53.
• Pedret, A. et al., 2019. Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial. Int. J. Obes. 43:1863-1868.
• Ramírez, V. T. et al., 2019. Differential functional selectivity and downstream signaling bias of ghrelin receptor antagonists and inverse agonists. FASEB J. 33 (1):518-531.
• Rodríguez-Luna, A. et al., 2019. Fucoxanthin and rosmarinic acid combination has anti-inflammatory effects through regulation of NLRP3 inflammasome in UVB-exposed HaCaT keratinocytes. Mar. Drugs. 17: 451.
• Samarra, I. et al., 2019. Gender-related differences on polyamine metabolome in liquid biopsies by a simple and sensitive two-step liquid-liquid extraction and LC-MS/MS. Biomolecules. 9: 779.
• Tarro, L. et al., 2019. Impact of a youth-led social marketing intervention run by adolescents to encourage healthy lifestyles among younger school peers (EYTO-Kids project): a parallel-cluster randomised controlled pilot study. Epidemiol. Community Health. 73:324-333.
• Torres-Fuentes, C. et al., 2019. Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling. FASEB J. 33 (12):fj.201901433R.
• Zhai, Z. et al., 2019. Synergy between probiotic Lactobacillus casei and milk to maintain barrier integrity of intestinal epithelial cells. J. Agric. Food Chem. 67:1955−1962.

2018

• Ardid-Ruíz, A. et al., 2018.  Potential involvement of peripheral Leptin/STAT3 signaling in the effects of resveratrol and its metabolites on reducing body fat accumulation . Nutrients. 10 (11): E1757.
• Blanco, J. et al., 2018. Oral exposure to silver nanoparticles increases oxidative stress markers in the liver of male rats and deregulates the insulin signalling pathway and p53 and cleaved caspase 3 protein expression. Food Chem. Toxicol. 115:398-404.
• Cantero, I. et al., 2018. Changes in lysophospholipids and liver status after weight loss: the RESMENA study. Nutr Metab (Lond). 15:51.
• Del Bas, J.M et al., 2018. Alterations in gut microbiota associated with a cafeteria diet and the physiological consequences in the host. Int. J. Obes. 42, 746-754.
• Gibert-Ramos, A. et al., 2018.  Consumption of cherry out of season changes white adipose tissue gene expression and morphology to a phenotype prone to fat accumulation.  Nutrients. 2018; 10: 1102.
• Gimeno, A. et al., 2018.  Combined ligand- and receptor-based virtual screening methodology to identify structurally diverse protein tyrosine phosphatase 1B Inhibitors. ChemMedChem. 13 (18): 1939-1948.
• Ginés, I. et al., 2018. Novel ex vivo experimental setup to assay the vectorial transepithelial enteroendocrine secretions of different intestinal segments. J. Agric. Food Chem. 66:11622−11629.
• Guirro, M. et al., 2018.  Multi-omics approach to elucidate the gut microbiota activity: Metaproteomics and metagenomics connection. *Electrophoresis.*39 (13): 1692-1701.
• Ibars, M. et al., 2018. Seasonal consumption of polyphenol-rich fruits affects the hypothalamic leptin signaling system in a photoperiod-dependent mode.  Sci Rep. 2018; 8 (1): 13572.
• Iglesias-Carres, L. et al., 2018. Optimized extraction by response surface methodology used for the characterization and quantification of phenolic compounds in whole red grapes (Vitis vinifera). Nutrients. 10: 1931.
• Llauradó, E. et al., 2018. The "Som la Pera" intervention: sustainability capacity evaluation of a peer-led social-marketing intervention to encourage healthy lifestyles among adolescents. Transl. Behav. Med. 8 (5):739-7.
• Mariné-Casadó, R. et al., 2018, Intake of an Obesogenic Cafeteria Diet Affects Body Weight, Feeding Behavior, and Glucose and Lipid Metabolism in a Photoperiod-Dependent Manner in F344 Rats. Front. Physiol. 9:1639.
• Mariné-Casadó, R. et al., 2018. The exposure to different photoperiods strongly modulates the glucose and lipid metabolisms of normoweight Fischer 344 rats. Front. Physiol. 9: 416.
• Mas-Capdevila, A. et al., 2018. Dose-related antihypertensive properties and the corresponding mechanisms of a chicken foot hydrolysate in hypertensive rats.  Nutrients. 10 (9): 1295.
• Melero, J. L. et al., 2018. Deciphering psoriasis. A bioinformatic approach. J. Dermatol. Sci. 89 (2):120-126.
• Miró-Abella, E. et al., 2018. Determination of trichothecenes in cereal matrices using subcritical water extraction followed by solid-phase extraction and liquid chromatography-tandem mass spectrometry. Food Anal. Methods. 11:1113-1121.
• Miró-Abella, E. et al., 2018. Monitoring and evaluation of the interaction between deoxynivalenol and gut microbiota in Wistar rats by mass spectrometry-based metabolomics and next-generation sequencing. Food Chem. Toxicol. 121:124-130.
• Moriña, D. et al., 2018. Effectiveness of a low-fat yoghurt supplemented with rooster comb extract on muscle strength in adults with mild knee pain and mechanisms of action on muscle regeneration. Food Funct. 9: 3244.
• Ojeda-Montes, M. J. et al., 2018. Activity and selectivity cliffs for DPP-IV inhibitors: Lessons we can learn from SAR studies and their application to virtual screening. Med. Res. Rev. 38:1874-1915.
• Pascual-Serrano, A. et al., 2018. Grape seed proanthocyanidins improve white adipose tissue expansion during diet-induced obesity development in rats. Int. J. Mol. Sci.19:2632.
• Tomas-Hernández, S. et al., 2018. Anti-inflammatory and proapoptotic properties of the natural compound o‑Orsellinaldehyde. J. Agric. Food Chem. 66: 10952−10963.
• Tomas-Hernández, S. et al., 2018. Resveratrol potently counteracts quercetin starvation-induced autophagy and sensitizes HepG2 cancer cells to apoptosis. Mol Nutr Food Res. 62: 1700610.

2017

• Aceves-Martins, M. et al., 2017. A school-based, peer-led, social marketing intervention to engage spanish adolescents in a healthy lifestyle ("We Are Cool"-Som la Pera Study): A parallel-cluster randomized controlled study. Child Obes. 13 (4):300-313.
• Aragonès, G. et al., 2017.  The importance of studying cell metabolism when testing the bioactivity of phenolic compounds.  *Trends Food Sci. Tech.*69: 230-242.
• Caimari, A. et al., 2017. Heat-killed Bifidobacterium animalis subsp. Lactis CECT 8145 increases lean mass and ameliorates metabolic syndrome in cafeteria-fed obese rats. J. Funct. Foods. 38: 251-263.
• Caimari, A. et al., 2017. Maternal intake of grape seed procyanidins during lactation induces insulin resistance and an adiponectin resistance-like phenotype in rat offspring. Sci Rep. 7 (1):12573.
• Gil-Cardoso, K. et al., 2017. Chronic supplementation with dietary proanthocyanidins protects from diet-induced intestinal alterations in obese rats. Mol. Nutr. Food Res. 61(8): 1601039.
• Ibars, M. et al., 2017. Proanthocyanidins potentiate hypothalamic leptin/STAT3 signalling and Pomc gene expression in rats with diet-induced obesity.  Int J Obes. 41 (1): 129-136.
• Margalef, M. et al., 2017. Flavanol plasma bioavailability is affected by metabolic syndrome in rats.  Food Chem. 231: 287-294.
• Margalef, M. et al., 2017. Rat health status affects bioavailability, target tissue levels, and bioactivity of grape seed flavanols.  Mol. Nutr. Food Res. 61 (2): 1600342.
• Miró-Abella, E. et al., 2017. Determination of mycotoxins in plant-based beverages using QuEChERS and liquid chromatography-tandem mass spectrometry.  Food Chem. 229: 366-372.
• Pascual-Serrano, A. et al., 2017.  Grape seed proanthocyanidin supplementation reduces adipocyte size and increases adipocyte number in obese rats.  Int J Obes. 41 (8): 1246-1255.
• Pons, Z. et al., 2017. Chronic administration of grape-seed polyphenols attenuates the development of hypertension and improves other cardiometabolic risk factors associated with the metabolic syndrome in cafeteria diet-fed rats.  Br. J. Nutr. 117 (2): 200-208.
• Shi, W. et al., 2017. Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet. Mol. Nutr. Food Res. 61 (8): 1600878.
• Suárez-García, S. et al 2017. Development and validation of a UHPLC-ESI-MS/MS method for the simultaneous quantification of mammal lysophosphatidylcholines and lysophosphatidylethanolamines in serum.  J Chromatogr B. 1055-1056: 86-97.
• Suárez-García, S. et al., 2017. Impact of a cafeteria diet and daily physical training on the rat serum metabolome.  PLoS One. 12 (2): e0171970.
• Suárez-García, S. et al., 2017.  Serum lysophospholipid levels are altered in dyslipidemic hamsters.  Sci Rep. 7 (1): 10431.
• Suárez, M. et al., 2017. Mediterranean diet and multi-ingredient-based interventions for the management of non-alcoholic fatty liver disease.  Nutrients. 9 (10): 1052.
• Suárez, M. et al., 2017.  Metabolomics: An emerging tool to evaluate the impact of nutritional and physiological challenges.  Trends Anal. Chem. 96: 79-88.
• Tarro, L. et al., 2017. A youth-led, social marketing intervention run by adolescents to encourage healthy lifestyles among younger school peers (EYTO-Kids Project): A protocol for pilot cluster randomized controlled trial (Spain). Int. J. Environ. Res. Public Health. 14: 923.

2016

• Alegret J. M. et al. 2016. Circulating endothelial microparticles are elevated in bicuspid aortic valve disease and related to aortic dilation.  Int J Cardiol. 217: 35-41.
• Aragonès, G. et al., 2016. Dietary proanthocyanidins boost hepatic NAD+ metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats.  Sci Rep. 6 (1): 24977.
• Aragonès, G. et al., 2016. Modulation of leptin resistance by food compounds. Mol. Nutr. Food Res. 60 (8): 1789-1803.
• Baiges, I. and Arola, L. 2016. COCOA (Theobroma cacao) polyphenol-rich extract increases the chronological lifespan of Saccharomyces cerevisiae. J. Frailty Aging. 5 (3):186-90.
• Bladé, C. et al., 2016. Proanthocyanidins in health and disease.  Biofactors. 42 (1): 5-12.
• Canela, N. et al., 2016. Analytical methods in sphingolipidomics: Quantitative and profiling approaches in food analysis.  J Chromatogr A. 2016; 1428: 16-38.
• Canela, N. et al., 2016. Foodomics imaging by mass spectrometry and magnetic resonance.  Electrophoresis. 37 (13): 1748-1767.
• Cigarroa, I. et al., 2016.  Treadmill intervention attenuates the cafeteria diet-induced impairment of stress-coping strategies in young adult female rats.  PLoS One. 11 (4): e0153687.
• Del Bas, J. M. et al., 2016. Impairment of lysophospholipid metabolism in obesity: altered plasma profile and desensitization to the modulatory properties of n-3 polyunsaturated fatty acids in a randomized controlled trial.  Am J Clin Nutr. 104 (2): 266-279.
• Ibero-Baraibar, I. et al., 2016.  Cocoa extract intake for 4 weeks reduces postprandial systolic blood pressure response of obese subjects, even after following an energy-restricted diet.  Food Nutr Res. 60: 30449.
• Margalef, M. et al., 2016. Gender-related similarities and differences in the body distribution of grape seed flavanols in rats.  Mol Nutr Food Res. 60 (4): 760-772.
• Margalef, M. et al., 2016. A.  Age related differences in the plasma kinetics of flavanols in rats.  J Nutr Biochem. 29: 90-96.
• Pons, Z. et al., 2016. Acute administration of single oral dose of grape seed polyphenols restores blood pressure in a rat model of metabolic syndrome: role of nitric oxide and prostacyclin.  Eur J Nutr. 55 (2): 749-758.
• Pons, Z. et al., 2016.  Grape seed flavanols decrease blood pressure via Sirt-1 and confer a vasoprotective pattern in rats.  J Funct Foods. 24: 164-172.
• Valls, R. M. et al., 2016.  Effects of low molecular weight procyanidin rich extract from french maritime pine bark on cardiovascular disease risk factors in stage-1 hypertensive subjects: Randomized, double-blind, crossover, placebo-controlled intervention trial.  Phytomedicine. 23 (12): 1451-1461.

2015

• Font JT, Quintanilla R, Font-Furnols M, et al. Effect of diet on body composition and blood biomarkers in a pig model to analyze human metabolic diseases. Ann Nutr Metab. 2015; 67: 295.
• Puiggròs F, Canela N, Arola L. Metabolome responses to physiological and nutritional challenges. Curr Opin Food Sci. 2015; 4: 111-115. doi: 10.1016/j.cofs.2015.06.001.
• López-Carreras N, Castillo J, Muguerza B, Aleixandre A. Endothelium-dependent vascular relaxing effects of different citrus and olive extracts in aorta rings from spontaneously hypertensive rats. Food Res Int. 2015; 77: 484-490. doi: 10.1016/j.foodres.2015.09.021
• Del Bas JM, Crescenti A, Arola-Arnal A, Oms-Oliu G, Arola L, Caimari A. Intake of grape procyanidins during gestation and lactation impairs reverse cholesterol transport and increases atherogenic risk indexes in adult offspring. J Nutr Biochem. 2015; 26 (12): 1670-1677. doi: 10.1016/j.jnutbio.2015.08.015.
• Crescenti A, Puiggròs F, Colomé A, et al. [Antiurolithiasic effect of a plant mixture of Herniaria glabra, Agropyron repens, Equisetum arvense and Sambucus nigra (Herbensurina®) in the prevention of experimentally induced nephrolithiasis in rats]. Arch Esp Urol. 2015; 68 (10): 739-749.
• Caimari A, Crescenti A, Puiggròs F, Boqué N, Arola L, del Bas JM. The intake of a high-fat diet and grape seed procyanidins induces gene expression changes in peripheral blood mononuclear cells of hamsters: capturing alterations in lipid and cholesterol metabolisms. Genes Nutr. 2015; 10 (1): 438. doi: 10.1007/s12263-014-0438-y.
• Solà R, Valls R-M, Martorell I, et al. A low-fat yoghurt supplemented with a rooster comb extract on muscle joint function in adults with mild knee pain: a randomized, double blind, parallel, placebo-controlled, clinical trial of efficacy. Food Funct. 2015; 6 (11): 3531-3539. doi: 10.1039/c5fo00321k.
• Del Bas JM, Caimari A, Ceresi E, et al. Differential effects of habitual chow-based and semi-purified diets on lipid metabolism in lactating rats and their offspring. Br J Nutr. 2015; 113 (5): 758-769. doi: 10.1017/S0007114514004358.
• Llauradó E, Aceves-Martins M, Tarro L, et al. A youth-led social marketing intervention to encourage healthy lifestyles, the EYTO (European Youth Tackling Obesity) project: a cluster randomised controlled0 trial in Catalonia, Spain. BMC Public Health. 2015; 15 (1): 607. doi: 10.1186/s12889-015-1920-1.
• Ribas-Latre A, Del Bas JM, Baselga-Escudero L, et al. Dietary proanthocyanidins modulate the rhythm of BMAL1 expression and induce RORα transactivation in HepG2 cells. J Funct Foods. 2015; 13: 336-344. doi: 10.1016/j.jff.2015.01.017
• Bravo FI, Felipe X, López-Fandiño R, Molina E. Skim milk protein distribution as a result of very high hydrostatic pressure. Food Res Int. 2015; 72: 74-79. doi: 10.1016/j.foodres.2015.03.014.
• Aguiló-Aguayo I, Suarez M, Plaza L, et al. Optimization of pulsed electric field pre-treatments to enhance health-promoting glucosinolates in broccoli flowers and stalk. J Sci Food Agric. 2015; 95 (9): 1868-1875. doi: 10.1002/jsfa.6891.
• Morrison MC, Mulder P, Stavro PM, et al. Replacement of Dietary Saturated Fat by PUFA-Rich Pumpkin Seed Oil Attenuates Non-Alcoholic Fatty Liver Disease and Atherosclerosis Development, with Additional Health Effects of Virgin over Refined Oil. Zhu X, ed. PLoS One. 2015; 10 (9): e0139196. doi: 10.1371/journal.pone.0139196.
• Margalef M, Pons Z, Iglesias-Carres L, Bravo FI, Muguerza B, Arola-Arnal A. Lack of Tissue Accumulation of Grape Seed Flavanols after Daily Long-Term Administration in Healthy and Cafeteria-Diet Obese Rats. J Agric Food Chem. 2015; 63 (45): 9996-10003. doi: 10.1021/acs.jafc.5b03856.
• Crescenti A, del Bas JM, Arola-Arnal A, Oms-Oliu G, Arola L, Caimari A. Grape seed procyanidins administered at physiological doses to rats during pregnancy and lactation promote lipid oxidation and up-regulate AMPK in the muscle of male offspring in adulthood. J Nutr Biochem. 2015; 26 (9): 912-920. doi: 10.1016/j.jnutbio.2015.03.003.
• Kelder T, Summer G, Caspers M, et al. White adipose tissue reference network: a knowledge resource for exploring health-relevant relations. Genes Nutr. 2015; 10 (1): 439. doi: 10.1007/s12263-014-0439-x.
• Ribas-Latre A, Baselga-Escudero L, Casanova E, et al. Chronic consumption of dietary proanthocyanidins modulates peripheral clocks in healthy and obese rats. J Nutr Biochem. 2015; 26 (2): 112-119. doi: 10.1016/j.jnutbio.2014.09.006.
• Del Bas JM, Crescenti A, Arola-Arnal A, Oms-Oliu G, Arola L, Caimari A. Grape seed procyanidin supplementation to rats fed a high-fat diet during pregnancy and lactation increases the body fat content and modulates the inflammatory response and the adipose tissue metabolism of the male offspring in youth. Int J Obes. 2015; 39 (1): 7-15. doi: 10.1038/ijo.2014.159.
• Quiñones M, Margalef M, Arola-Arnal A, Muguerza B, Miguel M, Aleixandre A. The blood pressure effect and related plasma levels of flavan-3-ols in spontaneously hypertensive rats. Food Funct. 2015; 6 (11): 3479-3489. doi: 10.1039/c5fo00547g.
• Martínez-Fernández L, Pons Z, Margalef M, Arola-Arnal A, Muguerza B. Regulation of vascular endothelial genes by dietary flavonoids: structure-expression relationship studies and the role of the transcription factor KLF-2. J Nutr Biochem. 2015; 26 (3): 277-284. doi: 10.1016/j.jnutbio.2014.11.003.
• Pedret A, Catalán Ú, Fernández-Castillejo S, et al. Impact of Virgin Olive Oil and Phenol-Enriched Virgin Olive Oils on the HDL Proteome in Hypercholesterolemic Subjects: A Double Blind, Randomized, Controlled, Cross-Over Clinical Trial (VOHF Study). Norata GD, ed. PLoS One. 2015; 10 (6): e0129160. doi: 10.1371/journal.pone.0129160.
• Caimari A, Puiggròs F, Suárez M, et al. The intake of a hazelnut skin extract improves the plasma lipid profile and reduces the lithocholic/deoxycholic bile acid faecal ratio, a risk factor for colon cancer, in hamsters fed a high-fat diet. Food Chem. 2015; 167: 138-144. doi: 10.1016/j.foodchem.2014.06.072.
• Ribas-Latre A, Del Bas JM, Baselga-Escudero L, et al. Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats. Mol Nutr Food Res. 2015; 59 (5): 865-878. doi: 10.1002/mnfr.201400571.
• Baselga-Escudero L, Pascual-Serrano A, Ribas-Latre A, et al. Long-term supplementation with a low dose of proanthocyanidins normalized liver miR-33a and miR-122 levels in high-fat diet-induced obese rats. Nutr Res. 2015; 35 (4): 337-345. doi: 10.1016/j.nutres.2015.02.008.
• Ribas-Latre A, Baselga-Escudero L, Casanova E, et al. Dietary proanthocyanidins modulate BMAL1 acetylation, Nampt expression and NAD levels in rat liver. Sci Rep. 2015; 5 (1): 10954. doi: 10.1038/srep10954.
• Margalef M, Pons Z, Bravo FI, Muguerza B, Arola-Arnal A. Tissue distribution of rat flavanol metabolites at different doses. J Nutr Biochem. 2015; 26 (10): 987-995. doi: 10.1016/j.jnutbio.2015.04.006.
• Salvadó MJ, Casanova E, Fernández-Iglesias A, Arola L, Bladé C. Roles of proanthocyanidin rich extracts in obesity. Food Funct. 2015; 6 (4): 1053-1071. doi: 10.1039/c4fo01035c.
• Margalef M, Pons Z, Bravo FI, Muguerza B, Arola-Arnal A. Plasma kinetics and microbial biotransformation of grape seed flavanols in rats. J Funct Foods. 2015; 12: 478-488. doi:10.1016/j.jff.2014.12.007.
• Garcia-Vallvé S, Guasch L, Tomas-Hernández S, et al. Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Ligand Choreography: Newcomers Take the Stage. J Med Chem. 2015; 58 (14): 5381-5394. doi: 10.1021/jm501155f.
• Gonzalez-Abuin N, Pinent M, Casanova-Marti A, Arola L, Blay M, Ardevol A. Procyanidins and their healthy protective effects against type 2 diabetes. Curr Med Chem. 2015; 22 (1): 39-50. doi: 0.2174/0929867321666140916115519.
• Valls R-M, Farràs M, Suárez M, et al. Effects of functional olive oil enriched with its own phenolic compounds on endothelial function in hypertensive patients. A randomised controlled trial. Food Chem. 2015; 167: 30-35. doi: 10.1016/j.foodchem.2014.06.107.
• Rodríguez-Gallego E, Guirro M, Riera-Borrull M, et al. Mapping of the circulating metabolome reveals α-ketoglutarate as a predictor of morbid obesity-associated non-alcoholic fatty liver disease. Int J Obes. 2015; 39 (2): 279-287. doi: 10.1038/ijo.2014.53.

2014

• Solà R, Valls R, Martorell I, et al. Effects of a low-fat yogurt supplemented with a rooster comb extract (mobilee®) on joint function in adults with mild knee pain: a randomized trial. Osteoarthr Cartil. 2014; 22: S325. doi: 10.1016/j.joca.2014.02.603.
• Puiggròs F, Salvadó M-J, Bladé C, Arola L. Differential Modulation of Apoptotic Processes by Proanthocyanidins as a Dietary Strategy for Delaying Chronic Pathologies. Crit Rev Food Sci Nutr. 2014; 54 (3): 277-291. doi: 10.1080/10408398.2011.565456.
• Ferrán A, Alegret JM, Subirana I, et al. Association Between rs2200733 and rs7193343 Genetic Variants and Atrial Fibrillation in a Spanish Population, and Meta-analysis of Previous Studies. Rev Española Cardiol (English Ed). 2014; 67 (10): 822-829. doi: 10.1016/j.rec.2013.12.019.
• Casanova E, Baselga-Escudero L, Ribas-Latre A, et al. Omega-3 polyunsaturated fatty acids and proanthocyanidins improve postprandial metabolic flexibility in rat. BioFactors. 2014; 40 (1): 146-156. doi: 10.1002/biof.1129.
• Blade C, Baselga-Escudero L, Arola-Arnal A. microRNAs as new targets of dietary polyphenols. Curr Pharm Biotechnol. 2014; 15 (4): 343-351. doi: 10.2174/1389201015666140711113553.
• Casanova E, Baselga-Escudero L, Ribas-Latre A, et al. Epigallocatechin gallate counteracts oxidative stress in docosahexaenoxic acid-treated myocytes. Biochim Biophys Acta - Bioenerg. 2014; 1837 (6): 783-791. doi: 10.1016/j.bbabio.2014.01.014.
• Laos S, Caimari A, Crescenti A, et al. Long-term intake of soyabean phytosterols lowers serum TAG and NEFA concentrations, increases bile acid synthesis and protects against fatty liver development in dyslipidaemic hamsters. Br J Nutr. 2014; 112 (5): 663-673. doi: 10.1017/S0007114514001342.
• Hide D, Ortega-Ribera M, Fernández-Iglesias A, et al. A novel form of the human manganese superoxide dismutase protects rat and human livers undergoing ischaemia and reperfusion injury. Clin Sci. 2014; 127 (8): 527-537. doi: 10.1042/CS20140125.
• Casanova E, Baselga-Escudero L, Ribas-Latre A, et al. Chronic intake of proanthocyanidins and docosahexaenoic acid improves skeletal muscle oxidative capacity in diet-obese rats. J Nutr Biochem. 2014; 25 (10): 1003-1010. doi: 10.1016/j.jnutbio.2014.05.003.
• Monrad JK, Suárez M, Motilva MJ, King JW, Srinivas K, Howard LR. Extraction of anthocyanins and flavan-3-ols from red grape pomace continuously by coupling hot water extraction with a modified expeller. Food Res Int. 2014; 65: 77-87. doi: 10.1016/j.foodres.2014.04.020.
• Fernández-Iglesias A, Quesada H, Díaz S, et al. Combination of grape seed proanthocyanidin extract and docosahexaenoic acid-rich oil increases the hepatic detoxification by GST mediated GSH conjugation in a lipidic postprandial state. Food Chem. 2014; 165: 14-20. doi: 10.1016/j.foodchem.2014.05.057.
• Joven J, March I, Espinel E, et al. Hibiscus sabdariffa extract lowers blood pressure and improves endothelial function. Mol Nutr Food Res. 2014; 58 (6): 1374-1378. doi: 10.1002/mnfr.201300774.
• Quiñones M, Guerrero L, Fernández-Vallinas S, et al. Involvement of nitric oxide and prostacyclin in the antihypertensive effect of low-molecular-weight procyanidin rich grape seed extract in male spontaneously hypertensive rats. J Funct Foods. 2014; 6: 419-427. doi: 10.1016/j.jff.2013.11.008.
• Margalef M, Pons Z, Muguerza B, Arola-Arnal A. A Rapid Method to Determine Colonic Microbial Metabolites Derived from Grape Flavanols in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry. J Agric Food Chem. 2014; 62 (31): 7698-7706. doi: 10.1021/jf5019752.
• Margalef M, Guerrero L, Pons Z, et al. A dose-response study of the bioavailability of grape seed proanthocyanidin in rat and lipid-lowering effects of generated metabolites in HepG2 cells. Food Res Int. 2014; 64: 500-507. doi: 10.1016/j.foodres.2014.07.019.
• Fernández-Iglesias A, Pajuelo D, Quesada H, et al. Grape seed proanthocyanidin extract improves the hepatic glutathione metabolism in obese Zucker rats. Mol Nutr Food Res. 2014; 58 (4): 727-737. doi: 10.1002/mnfr.201300455.
• Rojas C, Pan-Castillo B, Valls C, et al. Resveratrol Enhances Palmitate-Induced ER Stress and Apoptosis in Cancer Cells. Velasco G, ed. PLoS One. 2014; 9 (12): e113929. doi: 10.1002/mnfr.201300455.
• Lalanza JF, Caimari A, del Bas JM, et al. Effects of A Post-Weaning Cafeteria Diet In Young Rats: Metabolic Syndrome, Reduced Activity And Low Anxiety-Like Behaviour. Ashton N, ed. PLoS One. 2014; 9 (1): e85049. doi: 10.1371/journal.pone.0085049.
• Baselga-Escudero L, Bladé C, Ribas-Latre A, et al. Chronic supplementation of proanthocyanidins reduces postprandial lipemia and liver miR-33a and miR-122 levels in a dose-dependent manner in healthy rats. J Nutr Biochem. 2014; 25 (2): 151-156. doi: 10.1016/j.jnutbio.2013.09.014
• González-Abuín N, Martínez-Micaelo N, Margalef M, et al. A grape seed extract increases active glucagon-like peptide-1 levels after an oral glucose load in rats. Food Funct. 2014; 5 (9): 2357-2364. doi: 10.1039/c4fo00447g.
• Pons Z, Guerrero L, Margalef M, Arola L, Arola-Arnal A, Muguerza B. Effect of low molecular grape seed proanthocyanidins on blood pressure and lipid homeostasis in cafeteria diet-fed rats. J Physiol Biochem. 2014; 70 (2): 629-637. doi: 10.1007/s13105-014-0329-0.
• Rull A, Geeraert B, Aragonès G, et al. Rosiglitazone and Fenofibrate Exacerbate Liver Steatosis in a Mouse Model of Obesity and Hyperlipidemia. A Transcriptomic and Metabolomic Study. J Proteome Res. 2014; 13 (3): 1731-1743. doi: 10.1021/pr401230s.
• Baselga-Escudero L, Blade C, Ribas-Latre A, et al. Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells. Nucleic Acids Res. 2014; 42 (2): 882-892. doi: 10.1093/nar/gkt1011.
• Bolea E, Jiménez-Lamana J, Laborda F, et al. Detection and characterization of silver nanoparticles and dissolved species of silver in culture medium and cells by AsFlFFF-UV-Vis-ICPMS: application to nanotoxicity tests. Analyst. 2014; 139 (5): 914-922. doi: 10.1039/c3an01443f.